학술논문
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
Document Type
article
Author
Martin J. Blythe; Ayhan Kocer; Alejandro Rubio-Roldan; Tom Giles; Abdulkadir Abakir; Côme Ialy-Radio; Lee M. Wheldon; Oxana Bereshchenko; Stefano Bruscoli; Alexander Kondrashov; Joël R. Drevet; Richard D. Emes; Andrew D. Johnson; John R. McCarrey; Daniel Gackowski; Ryszard Olinski; Julie Cocquet; Jose L. Garcia-Perez; Alexey Ruzov
Source
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Blythe et al investigate the patterns of oxidized forms of the 5-methylcytosine DNA modification during spermatogenesis. They find that open reading frames of evolutionarily young and transcriptionally active LINE-1 retrotransposons are enriched in 5-carboxylcytosine (5caC) during spermatid maturation, suggesting a link between 5cac and LINE-1 activity.