학술논문
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
Document Type
article
Author
Anneliese S. Ashhurst; Matt D. Johansen; Joshua W. C. Maxwell; Skye Stockdale; Caroline L. Ashley; Anupriya Aggarwal; Rezwan Siddiquee; Stefan Miemczyk; Duc H. Nguyen; Joel P. Mackay; Claudio Counoupas; Scott N. Byrne; Stuart Turville; Megan Steain; James A. Triccas; Philip M. Hansbro; Richard J. Payne; Warwick J. Britton
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Current vaccines against SARS-CoV-2 reduce mortality but are less effective in preventing infection. Here the authors show that intranasal vaccination with a subunit vaccine including an TLR2-stimulating adjuvant induces strong neutralising antibody and T-cell responses against SARS-CoV-2 in the lungs that protect against infection.