학술논문
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
Document Type
article
Author
Nilda Vanesa Ayala-Nunez; Gautier Follain; François Delalande; Aurélie Hirschler; Emma Partiot; Gillian L. Hale; Brigid C. Bollweg; Judith Roels; Maxime Chazal; Florian Bakoa; Margot Carocci; Sandrine Bourdoulous; Orestis Faklaris; Sherif R. Zaki; Anita Eckly; Béatrice Uring-Lambert; Frédéric Doussau; Sarah Cianferani; Christine Carapito; Frank M. J. Jacobs; Nolwenn Jouvenet; Jacky G. Goetz; Raphael Gaudin
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.