학술논문
On-demand synthesis of phosphoramidites
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The poor bench stability of phosphoramidites is a drawback for fast automised chemical oligonucleotide synthesis. Here, the authors report a method for on-demand flow synthesis of phosphoramidites within short reaction times, in near-quantitative yields and sufficient purity for integration with DNA synthesizers.