학술논문
DNA methylation and stroke prognosis: an epigenome-wide association study
Document Type
article
Author
Joan Jiménez-Balado; Isabel Fernández-Pérez; Cristina Gallego-Fábrega; Uxue Lazcano; Carolina Soriano-Tárraga; Marta Vallverdú-Prats; Marina Mola-Caminal; Lucía Rey-Álvarez; Adrià Macias-Gómez; Antoni Suárez-Pérez; Eva Giralt-Steinhauer; Ana Rodríguez-Campello; Elisa Cuadrado-Godia; Ángel Ois; Manel Esteller; Jaume Roquer; Israel Fernández-Cadenas; Jordi Jiménez-Conde
Source
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)
Subject
Language
English
ISSN
1868-7083
Abstract
Abstract Background and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there is a significant variability among individuals that may be attributed to genetics and epigenetics, including DNA methylation (DNAm). We aimed to study the association between DNAm and stroke prognosis. Methods and results To that aim, we conducted a two-phase study (discovery-replication and meta-analysis) in Caucasian patients with ischemic stroke from two independent centers (BasicMar [discovery, N = 316] and St. Pau [replication, N = 92]). Functional outcome was assessed using the modified Rankin Scale (mRS) at three months after stroke, being poor outcome defined as mRS > 2. DNAm was determined using the 450K and EPIC BeadChips in whole-blood samples collected within the first 24 h. We searched for differentially methylated positions (DMPs) in 370,344 CpGs, and candidates below p-value