학술논문
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
Document Type
article
Author
Dawn M. Dudley; Christina M. Newman; Joseph Lalli; Laurel M. Stewart; Michelle R. Koenig; Andrea M. Weiler; Matthew R. Semler; Gabrielle L. Barry; Katie R. Zarbock; Mariel S. Mohns; Meghan E. Breitbach; Nancy Schultz-Darken; Eric Peterson; Wendy Newton; Emma L. Mohr; Saverio Capuano III; Jorge E. Osorio; Shelby L. O’Connor; David H. O’Connor; Thomas C. Friedrich; Matthew T. Aliota
Source
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.