학술논문
Orexin Receptor Targets for Anti-Relapse Medication Development in Drug Addiction
Document Type
article
Author
Source
Pharmaceuticals, Vol 4, Iss 6, Pp 804-821 (2011)
Subject
Language
English
ISSN
1424-8247
Abstract
Drug addiction is a chronic illness characterized by high rates of relapse. Relapse to drug use can be triggered by re-exposure to drug-associated cues, stressful events, or the drug itself after a period of abstinence. Pharmacological intervention to reduce the impact of relapse-instigating factors offers a promising target for addiction treatment. Growing evidence has implicated an important role of the orexin/hypocretin system in drug reward and drug-seeking, including animal models of relapse. Here, we review the evidence for the role of orexins in modulating reward and drug-seeking in animal models of addiction and the potential for orexin receptors as specific targets for anti-relapse medication approaches.