학술논문
Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort
Document Type
article
Author
Sabri Soussi; Divya Sharma; Peter Jüni; Gerald Lebovic; Laurent Brochard; John C. Marshall; Patrick R. Lawler; Margaret Herridge; Niall Ferguson; Lorenzo Del Sorbo; Elodie Feliot; Alexandre Mebazaa; Erica Acton; Jason N. Kennedy; Wei Xu; Etienne Gayat; Claudia C. Dos Santos; the FROG-ICU; CCCTBG trans-trial group study for InFACT - the International Forum for Acute Care Trialists
Source
Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
1364-8535
Abstract
Abstract Background Late mortality risk in sepsis-survivors persists for years with high readmission rates and low quality of life. The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biological profiles at ICU discharge and late adverse events using an unsupervised analysis. Methods In the original FROG-ICU prospective, observational, multicenter study, intensive care unit (ICU) patients with sepsis on admission (Sepsis-3) were identified (N = 655). Among them, 467 were discharged alive from the ICU and included in the current study. Latent class analysis was applied to identify distinct sepsis-survivors clinical classes using readily available data at ICU discharge. The primary endpoint was one-year mortality after ICU discharge. Results At ICU discharge, two distinct subtypes were identified (A and B) using 15 readily available clinical and biological variables. Patients assigned to subtype B (48% of the studied population) had more impaired cardiovascular and kidney functions, hematological disorders and inflammation at ICU discharge than subtype A. Sepsis-survivors in subtype B had significantly higher one-year mortality compared to subtype A (respectively, 34% vs 16%, p