학술논문
Differentiation of viral and autoimmune central nervous system inflammation by kynurenine pathway
Document Type
article
Author
Source
Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2228-2234 (2021)
Subject
Language
English
ISSN
2328-9503
Abstract
Abstract Objective To determine whether the metabolites of Kynurenine pathway (KP) could serve as biomarkers for distinguishing between viral CNS infections and autoimmune neuroinflammatory diseases, especially anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARE) and herpes virus encephalitis (HSE). Methods This study enrolled CSF samples from 76 patients with viral CNS infections, autoimmune neuroinflammatory, and non‐inflammatory neurological diseases. We measured cerebrospinal fluid (CSF) concentrations of tryptophan (Trp) and kynurenine (Kyn) by ELISA. Results Kyn concentrations and Kyn/Trp ratios were highly increased (p