학술논문
SARS-CoV-2 viral load is associated with increased disease severity and mortality
Document Type
article
Author
Jesse Fajnzylber; James Regan; Kendyll Coxen; Heather Corry; Colline Wong; Alexandra Rosenthal; Daniel Worrall; Francoise Giguel; Alicja Piechocka-Trocha; Caroline Atyeo; Stephanie Fischinger; Andrew Chan; Keith T. Flaherty; Kathryn Hall; Michael Dougan; Edward T. Ryan; Elizabeth Gillespie; Rida Chishti; Yijia Li; Nikolaus Jilg; Dusan Hanidziar; Rebecca M. Baron; Lindsey Baden; Athe M. Tsibris; Katrina A. Armstrong; Daniel R. Kuritzkes; Galit Alter; Bruce D. Walker; Xu Yu; Jonathan Z. Li; The Massachusetts Consortium for Pathogen Readiness
Source
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.