학술논문
Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review
Document Type
article
Author
Johanna K. Rickel; Daria Zeeb; Susanne Knake; Hans Urban; Jürgen Konczalla; Katharina J. Weber; Pia S. Zeiner; Axel Pagenstecher; Elke Hattingen; André Kemmling; Emmanouil Fokas; Sebastian Adeberg; Robert Wolff; Martin Sebastian; Tillmann Rusch; Michael W. Ronellenfitsch; Katja Menzler; Lena Habermehl; Leona Möller; Marcus Czabanka; Christopher Nimsky; Lars Timmermann; Christian Grefkes; Joachim P. Steinbach; Felix Rosenow; Leena Kämppi; Adam Strzelczyk
Source
Neurological Research and Practice, Vol 6, Iss 1, Pp 1-14 (2024)
Subject
Language
English
ISSN
2524-3489
Abstract
Abstract Objective Brain tumors and metastases account for approximately 10% of all status epilepticus (SE) cases. This study described the clinical characteristics, treatment, and short- and long-term outcomes of this population. Methods This retrospective, multi-center cohort study analyzed all brain tumor patients treated for SE at the university hospitals of Frankfurt and Marburg between 2011 and 2017. Results The 208 patients (mean 61.5 ± 14.7 years of age; 51% male) presented with adult-type diffuse gliomas (55.8%), metastatic entities (25.5%), intracranial extradural tumors (14.4%), or other tumors (4.3%). The radiological criteria for tumor progression were evidenced in 128 (61.5%) patients, while 57 (27.4%) were newly diagnosed with tumor at admission and 113 (54.3%) had refractory SE. The mean hospital length of stay (LOS) was 14.8 days (median 12.0, range 1–57), 171 (82.2%) patients required intensive care (mean LOS 8.9 days, median 5, range 1–46), and 44 (21.2%) were administered mechanical ventilation. All patients exhibited significant functional status decline (modified Rankin Scale) post-SE at discharge (p