학술논문
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Document Type
article
Author
Sameer Agnihotri; Suganth Suppiah; Peter D. Tonge; Shahrzad Jalali; Arnavaz Danesh; Jeffery P. Bruce; Yasin Mamatjan; George Klironomos; Lior Gonen; Karolyn Au; Sheila Mansouri; Sharin Karimi; Felix Sahm; Andreas von Deimling; Michael D. Taylor; Normand J. Laperriere; Trevor J. Pugh; Kenneth D. Aldape; Gelareh Zadeh
Source
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.