학술논문
Prevalence and factors associated with tuberculosis infection in India
Document Type
article
Author
Sriram Selvaraju; Banurekha Velayutham; Raghuram Rao; Kiran Rade; Kannan Thiruvengadam; Smita Asthana; Rakesh Balachandar; Sampada Dipak Bangar; Avi Kumar Bansal; Jyothi Bhat; Vishal Chopra; Dasarathi Das; Shantha Dutta; Kangjam Rekha Devi; Gaurav Raj Dwivedi; Arshad Kalliath; Avula Laxmaiah; Major Madhukar; Amarendra Mahapatra; Suman Sundar Mohanty; Chethana Rangaraju; Jyotirmayee Turuk; Pradeep Aravindan Menon; Rajendran Krishnan; Manjula Singh; Krithikaa Sekar; Aby Robinson; Alka Turuk; Nivethitha N. Krishnan; Nivetha Srinivasan; Catherine Rexy; M. Suresh; Luke Elizabeth Hanna; Avijit H Choudhury; Malik Parmar; Ranjani Ramachandran; Nishant Kumar; Rajendra Panduranga Joshi; Somashekar Narasimhaiah; Padmapriyadarsini Chandrasekaran; A.M. Khan; Samiran Panda; Balram Bhargava
Source
Journal of Infection and Public Health, Vol 16, Iss 12, Pp 2058-2065 (2023)
Subject
Language
English
ISSN
1876-0341
85586021
85586021
Abstract
Background: The risk of tuberculosis (TB) disease is higher in individuals with TB infection. In a TB endemic country like India, it is essential to understand the current burden of TB infection at the population level. The objective of the present analysis is to estimate the prevalence of TB infection in India and to explore the factors associated with TB infection. Methods: Individuals aged > 15 years in the recently completed National TB prevalence survey in India who were tested for TB infection by QuantiFERON-TB Gold Plus (QFT-Plus) assay were considered for this sub-analysis. TB infection was defined as positive by QFT-Plus (value >0.35 IU/ml). The estimates for prevalence, prevalence ratio (PR) and adjusted risk ratio (aRR) estimates with 95% confidence intervals (CIs) were calculated. Results: Of the 16864 individuals analysed, the prevalence of TB infection was 22.6% (95% CI:19.4 −25.8). Factors more likely to be associated with TB infection include age > 30 years (aRR:1.49;95% CI:1.29–1.73), being male (aRR:1.26; 95%CI: 1.18–1.34), residing in urban location (aRR:1.58; 95%CI: 1.03–2.43) and past history of TB (aRR:1.49; 95%CI: 1.26–1.76). Conclusion: About one fourth (22.6%) of the individuals were infected with TB in India. Individuals aged > 30 years, males, residing in urban location, and those with past history of TB were more likely to have TB infection. Targeted interventions for prevention of TB and close monitoring are essential to reduce the burden of TB in India.