학술논문
CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
Document Type
article
Author
Victor L. Villemagne; Antoine Leuzy; Sandra Sanabria Bohorquez; Santiago Bullich; Hitoshi Shimada; Christopher C. Rowe; Pierrick Bourgeat; Brian Lopresti; Kun Huang; Natasha Krishnadas; Jurgen Fripp; Yuhei Takado; Alexandra Gogola; Davneet Minhas; Robby Weimer; Makoto Higuchi; Andrew Stephens; Oskar Hansson; Vincent Doré; Alzheimer's Disease Neuroimaging Initiative and the AIBL research group
Source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 3, Pp n/a-n/a (2023)
Subject
Language
English
ISSN
2352-8729
Abstract
Abstract INTRODUCTION Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD One thousand forty‐five participants underwent tau scans with either 18F‐flortaucipir, 18F‐MK6240, 18F‐PI2620, 18F‐PM‐PBB3, 18F‐GTP1, or 18F‐RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauRz, was constructed. RESULTS None of the regions known to display off‐target signal were included in the masks. The CenTauRz allows robust discrimination between low and high levels of tau deposits. DISCUSSION We constructed several tau‐specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur‐project.