학술논문
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival
Document Type
article
Author
Sandeep K. Singhal; Jung S. Byun; Samson Park; Tingfen Yan; Ryan Yancey; Ambar Caban; Sara Gil Hernandez; Stephen M. Hewitt; Heike Boisvert; Stephanie Hennek; Mark Bobrow; Md Shakir Uddin Ahmed; Jason White; Clayton Yates; Andrew Aukerman; Rami Vanguri; Rohan Bareja; Romina Lenci; Paula Lucia Farré; Adriana De Siervi; Anna María Nápoles; Nasreen Vohra; Kevin Gardner
Source
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Subject
Language
English
ISSN
2399-3642
Abstract
Through automated image analysis, Singhal et al quantify nuclear versus cytoplasmic distribution of the Kaiso transcription factor in breast cancer patient tissue. They find that Kaiso distribution correlates with breast cancer subtype and overall survival, and discover a link between cytoplasmic Kaiso and autophagy marker LC3.