학술논문
O-GlcNAcylated p53 in the liver modulates hepatic glucose production
Document Type
article
Author
Maria J. Gonzalez-Rellan; Marcos F. Fondevila; Uxia Fernandez; Amaia Rodríguez; Marta Varela-Rey; Christelle Veyrat-Durebex; Samuel Seoane; Ganeko Bernardo; Fernando Lopitz-Otsoa; David Fernández-Ramos; Jon Bilbao; Cristina Iglesias; Eva Novoa; Cristina Ameneiro; Ana Senra; Daniel Beiroa; Juan Cuñarro; Maria DP Chantada-Vazquez; Maria Garcia-Vence; Susana B. Bravo; Natalia Da Silva Lima; Begoña Porteiro; Carmen Carneiro; Anxo Vidal; Sulay Tovar; Timo D. Müller; Johan Ferno; Diana Guallar; Miguel Fidalgo; Guadalupe Sabio; Stephan Herzig; Won Ho Yang; Jin Won Cho; Maria Luz Martinez-Chantar; Roman Perez-Fernandez; Miguel López; Carlos Dieguez; Jose M. Mato; Oscar Millet; Roberto Coppari; Ashwin Woodhoo; Gema Fruhbeck; Ruben Nogueiras
Source
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.