학술논문
Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC: the RALLY protocol
Document Type
article
Author
Daan Andel; Marnix G. E. H. Lam; Joep de Bruijne; Maarten L. J. Smits; Arthur J. A. T. Braat; Adriaan Moelker; Erik Vegt; Simeon J. S. Ruiter; Walter Noordzij; Gianluca Grazi; Giulio E. Vallati; Roel J. Bennink; Otto M. van Delden; Onno W. Kranenburg; Jan N. M. Ijzermans; Maarten W. Nijkamp; Joris I. Erdmann; Rosa Sciuto; Jeroen Hagendoorn; Inne H. M. Borel Rinkes
Source
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Background High dose unilobar radioembolization (also termed ‘radiation lobectomy’)—the transarterial unilobar infusion of radioactive microspheres as a means of controlling tumour growth while concomitantly inducing future liver remnant hypertrophy—has recently gained interest as induction strategy for surgical resection. Prospective studies on the safety and efficacy of the unilobar radioembolization-surgery treatment algorithm are lacking. The RALLY study aims to assess the safety and toxicity profile of holmium-166 unilobar radioembolization in patients with hepatocellular carcinoma ineligible for surgery due to insufficiency of the future liver remnant. Methods The RALLY study is a multicenter, interventional, non-randomized, open-label, non-comparative safety study. Patients with hepatocellular carcinoma who are considered ineligible for surgery due to insufficiency of the future liver remnant (