학술논문
Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly
Document Type
article
Author
Marjetka Podobnik; Peter Savory; Nejc Rojko; Matic Kisovec; Neil Wood; Richard Hambley; Jonathan Pugh; E. Jayne Wallace; Luke McNeill; Mark Bruce; Idlir Liko; Timothy M. Allison; Shahid Mehmood; Neval Yilmaz; Toshihide Kobayashi; Robert J. C. Gilbert; Carol V. Robinson; Lakmal Jayasinghe; Gregor Anderluh
Source
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Pore-forming toxins act by forming oligomeric pores in lipid membranes. Here the authors report the crystal structure of the lysenin pore, providing insights into the assembly and function of the pore in addition to suggesting that its properties make lysenin potentially well-suited for nanopore sensing applications.