학술논문
Genetically predicted waist circumference and risk of atrial fibrillation
Document Type
article
Author
Source
Chinese Medical Journal, Vol 137, Iss 1, Pp 82-86 (2024)
Subject
Language
English
ISSN
0366-6999
2542-5641
00000000
2542-5641
00000000
Abstract
Abstract. Introduction:. Observational studies have revealed an association between waist circumference (WC) and atrial fibrillation (AF). However, it is difficult to infer a causal relationship from observational studies because the observed associations could be confounded by unknown risk factors. Therefore, the causal role of WC in AF is unclear. This study was designed to investigate the causal association between WC and AF using a two-sample Mendelian randomization (MR) analysis. Methods:. In our two-sample MR analysis, the genetic variation used as an instrumental variable for MR was acquired from a genome-wide association study (GWAS) of WC (42 single nucleotide polymorphisms with a genetic significance of P