학술논문
The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
Document Type
article
Source
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Subject
Language
English
ISSN
2372-3556
23723556
23723556
Abstract
The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.