학술논문
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Autophagy is a cellular process for recycling cell constituents, and is essential for T cell activation, but its function in T cell polarization is still unclear. Here the authors show that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 homeostasis and antitumour immunity.