학술논문
Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration
Document Type
article
Author
Marketa Kaucka; Alberto Joven Araus; Marketa Tesarova; Joshua D. Currie; Johan Boström; Michaela Kavkova; Julian Petersen; Zeyu Yao; Anass Bouchnita; Andreas Hellander; Tomas Zikmund; Ahmed Elewa; Phillip T. Newton; Ji-Feng Fei; Andrei S. Chagin; Kaj Fried; Elly M. Tanaka; Jozef Kaiser; András Simon; Igor Adameyko
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Normal limb development relies on synchronized formation of cartilage and bone. Here, the authors show that in salamander limb regeneration these processes are decoupled: ossification occurs after the final size of regenerating cartilage is reached, allowing fast regeneration and leading to bulky bones.