학술논문
Genetic and Protein Network Underlying the Convergence of Rett-Syndrome-like (RTT-L) Phenotype in Neurodevelopmental Disorders
Document Type
article
Author
Eric Frankel; Avijit Podder; Megan Sharifi; Roshan Pillai; Newell Belnap; Keri Ramsey; Julius Dodson; Pooja Venugopal; Molly Brzezinski; Lorida Llaci; Brittany Gerald; Gabrielle Mills; Meredith Sanchez-Castillo; Chris D. Balak; Szabolcs Szelinger; Wayne M. Jepsen; Ashley L. Siniard; Ryan Richholt; Marcus Naymik; Isabelle Schrauwen; David W. Craig; Ignazio S. Piras; Matthew J. Huentelman; Nicholas J. Schork; Vinodh Narayanan; Sampathkumar Rangasamy
Source
Cells, Vol 12, Iss 10, p 1437 (2023)
Subject
Language
English
ISSN
2073-4409
Abstract
Mutations of the X-linked gene encoding methyl-CpG-binding protein 2 (MECP2) cause classical forms of Rett syndrome (RTT) in girls. A subset of patients who are recognized to have an overlapping neurological phenotype with RTT but are lacking a mutation in a gene that causes classical or atypical RTT can be described as having a ‘Rett-syndrome-like phenotype (RTT-L). Here, we report eight patients from our cohort diagnosed as having RTT-L who carry mutations in genes unrelated to RTT. We annotated the list of genes associated with RTT-L from our patient cohort, considered them in the light of peer-reviewed articles on the genetics of RTT-L, and constructed an integrated protein–protein interaction network (PPIN) consisting of 2871 interactions connecting 2192 neighboring proteins among RTT- and RTT-L-associated genes. Functional enrichment analysis of RTT and RTT-L genes identified a number of intuitive biological processes. We also identified transcription factors (TFs) whose binding sites are common across the set of RTT and RTT-L genes and appear as important regulatory motifs for them. Investigation of the most significant over-represented pathway analysis suggests that HDAC1 and CHD4 likely play a central role in the interactome between RTT and RTT-L genes.