학술논문
Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
Document Type
article
Author
Janek S. Walker; Zachary A. Hing; Steven Sher; James Cronin; Katie Williams; Bonnie Harrington; Jordan N. Skinner; Casey B. Cempre; Charles T. Gregory; Alexander Pan; Max Yano; Larry P. Beaver; Brandi R. Walker; Jadwiga M. Labanowska; Nyla A. Heerema; Krzysztof Mrózek; Jennifer A. Woyach; Amy S. Ruppert; Amy Lehman; Hatice Gulcin Ozer; Vincenzo Coppola; Pearlly Yan; John C. Byrd; James S. Blachly; Rosa Lapalombella
Source
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.