학술논문
Course and Lethality of SARS-CoV-2 Epidemic in Nursing Homes after Vaccination in Florence, Italy
Document Type
article
Author
Giulia Rivasi; Matteo Bulgaresi; Enrico Mossello; Primo Buscemi; Chiara Lorini; Daniela Balzi; Riccardo Barucci; Ilaria Del Lungo; Salvatore Gangemi; Sante Giardini; Cecilia Piga; Eleonora Barghini; Serena Boni; Giulia Bulli; Paolo Carrai; Andrea Crociani; Antonio Faraone; Aldo Lo Forte; Letizia Martella; Simone Pupo; Giacomo Fortini; Irene Marozzi; Giulia Bandini; Claudia Cosma; Lorenzo Stacchini; Gabriele Vaccaro; Lorenzo Baggiani; Giancarlo Landini; Guglielmo Bonaccorsi; Andrea Ungar; Enrico Benvenuti
Source
Vaccines, Vol 9, Iss 10, p 1174 (2021)
Subject
Language
English
ISSN
2076-393X
Abstract
Evidence on the effectiveness of SARS-CoV-2 vaccines in nursing home (NHs) residents is limited. We examined the impact of the BNT162b2 mRNA SARS-CoV-2 vaccine on the course of the epidemic in NHs in the Florence Health District, Italy, before and after vaccination. Moreover, we assessed survival and hospitalization by vaccination status in SARS-CoV-2-positive cases occurring during the post-vaccination period. We calculated the weekly infection rates during the pre-vaccination (1 October–26 December 2020) and post-vaccination period (27 December 2020–31 March 2021). Cox analysis was used to analyze survival by vaccination status. The study involved 3730 residents (mean age 84, 69% female). Weekly infection rates fluctuated during the pre-vaccination period (1.8%–6.5%) and dropped to zero during the post-vaccination period. Nine unvaccinated (UN), 56 partially vaccinated (PV) and 35 fully vaccinated (FV) residents tested SARS-CoV-2+ during the post-vaccination period. FV showed significantly lower hospitalization and mortality rates than PV and UV (hospitalization: FV 3%, PV 14%, UV 33%; mortality: FV 6%, PV 18%, UV 56%). The death risk was 84% and 96% lower in PV (HR 0.157, 95%CI 0.049–0.491) and FV (HR 0.037, 95%CI 0.006–0.223) versus UV. SARS-CoV-2 vaccination was followed by a marked decline in infection rates and was associated with lower morbidity and mortality among infected NH residents.