학술논문
Spatial competition constrains resistance to targeted cancer therapy
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Adaptive therapy aims to control tumours by exploiting competition between therapy-sensitive and resistant cells. Here, the authors show that tumour spatial structure is a critical parameter for adaptive therapy as competition for space increases fitness differentials, allowing suppression of resistance with low-dose treatments.