학술논문
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Document Type
article
Author
Charles C. Bell; Katie A. Fennell; Yih-Chih Chan; Florian Rambow; Miriam M. Yeung; Dane Vassiliadis; Luis Lara; Paul Yeh; Luciano G. Martelotto; Aljosja Rogiers; Brandon E. Kremer; Olena Barbash; Helai P. Mohammad; Timothy M. Johanson; Marian L. Burr; Arindam Dhar; Natalie Karpinich; Luyi Tian; Dean S. Tyler; Laura MacPherson; Junwei Shi; Nathan Pinnawala; Chun Yew Fong; Anthony T. Papenfuss; Sean M. Grimmond; Sarah-Jane Dawson; Rhys S. Allan; Ryan G. Kruger; Christopher R. Vakoc; David L. Goode; Shalin H. Naik; Omer Gilan; Enid Y. N. Lam; Jean-Christophe Marine; Rab K. Prinjha; Mark A. Dawson
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enhancer function as important modulators of resistance.