학술논문
Genetic map of regional sulcal morphology in the human brain from UK biobank data
Document Type
article
Author
Benjamin B. Sun; Stephanie J. Loomis; Fabrizio Pizzagalli; Natalia Shatokhina; Jodie N. Painter; Christopher N. Foley; Biogen Biobank Team; Megan E. Jensen; Donald G. McLaren; Sai Spandana Chintapalli; Alyssa H. Zhu; Daniel Dixon; Tasfiya Islam; Iyad Ba Gari; Heiko Runz; Sarah E. Medland; Paul M. Thompson; Neda Jahanshad; Christopher D. Whelan
Source
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans, revealing insights into the processes guiding cortical development and genetic correlations with neuropsychiatric phenotypes.