학술논문
Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males
Document Type
article
Author
Margherita Baldassarri; Nicola Picchiotti; Francesca Fava; Chiara Fallerini; Elisa Benetti; Sergio Daga; Floriana Valentino; Gabriella Doddato; Simone Furini; Annarita Giliberti; Rossella Tita; Sara Amitrano; Mirella Bruttini; Susanna Croci; Ilaria Meloni; Anna Maria Pinto; Nicola Iuso; Chiara Gabbi; Francesca Sciarra; Mary Anna Venneri; Marco Gori; Maurizio Sanarico; Francis P. Crawley; Uberto Pagotto; Flaminia Fanelli; Marco Mezzullo; Elena Dominguez-Garrido; Laura Planas-Serra; Agatha Schlüter; Roger Colobran; Pere Soler-Palacin; Pablo Lapunzina; Jair Tenorio; Aurora Pujol; Maria Grazia Castagna; Marco Marcelli; Andrea M. Isidori; Alessandra Renieri; Elisa Frullanti; Francesca Mari
Source
EBioMedicine, Vol 65, Iss , Pp 103246- (2021)
Subject
Language
English
ISSN
2352-3964
Abstract
Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Findings: Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men