학술논문
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
Document Type
article
Author
Source
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.