학술논문
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
Document Type
article
Author
Itziar de Rojas; Isabel Hernández; Laura Montrreal; Inés Quintela; Miguel Calero; Jose Luís Royo; Raquel Huerto Vilas; Antonio González-Pérez; Emilio Franco-Macías; Juan Macías; Manuel Menéndez-González; Ana Frank-García; Mónica Diez-Fairen; Carmen Lage; Sebastián García-Madrona; Nuria Aguilera; Pablo García-González; Raquel Puerta; Oscar Sotolongo-Grau; Silvia Alonso-Lana; Alberto Rábano; Alfonso Arias Pastor; Ana Belén Pastor; Anaïs Corma-Gómez; Angel Martín Montes; Carmen Martínez Rodríguez; Dolores Buiza-Rueda; Maria Teresa Periñán; Eloy Rodriguez-Rodriguez; Ignacio Alvarez; Irene Rosas Allende; Juan A. Pineda; María Bernal Sánchez-Arjona; Marta Fernández-Fuertes; Silvia Mendoza; Teodoro del Ser; Guillermo Garcia-Ribas; Pascual Sánchez-Juan; Pau Pastor; María J. Bullido; Victoria Álvarez; Luis M. Real; Pablo Mir; Gerard Piñol-Ripoll; Jose María García-Alberca; Miguel Medina; Adelina Orellana; Chris R. Butler; Marta Marquié; María Eugenia Sáez; Ángel Carracedo; Lluís Tárraga; Mercè Boada; Agustín Ruiz
Source
Journal of Personalized Medicine, Vol 11, Iss 12, p 1318 (2021)
Subject
Language
English
ISSN
2075-4426
Abstract
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.