학술논문

Non-T-depleted haploidentical transplantation with post-transplant cyclophosphamide in patients with secondary versus de novo AML in first complete remission: a study from the ALWP/EBMT
Document Type
article
Source
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-15 (2023)
Subject
Haploidentical allogeneic stem cell transplantation
Post-transplantation cyclophosphamide
Secondary acute myeloid leukemia
De novo acute myeloid leukemia
Transplantation outcomes
Diseases of the blood and blood-forming organs
RC633-647.5
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Language
English
ISSN
1756-8722
Abstract
Abstract We compared outcomes of adult patients with secondary acute myeloid leukemia (sAML) versus de novo AML after non-T-depleted haploidentical stem cell transplant (HaploSCT) with post-transplant cyclophosphamide (PTCy). Seventeen hundred and eleven AML patients (sAML-231, de novo-1480) in first complete remission transplanted from 2010 to 2021, were included. Patients with de novo AML were younger, median age 55.8 versus 60.8 years, p