학술논문
Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility
Document Type
article
Author
Miriam Cerván-Martín; Frank Tüttelmann; Alexandra M. Lopes; Lara Bossini-Castillo; Rocío Rivera-Egea; Nicolás Garrido; Saturnino Lujan; Gema Romeu; Samuel Santos-Ribeiro; José A. Castilla; M. Carmen Gonzalvo; Ana Clavero; Vicente Maldonado; F. Javier Vicente; Sara González-Muñoz; Andrea Guzmán-Jiménez; Miguel Burgos; Rafael Jiménez; Alberto Pacheco; Cristina González; Susana Gómez; David Amorós; Jesus Aguilar; Fernando Quintana; Carlos Calhaz-Jorge; Ana Aguiar; Joaquim Nunes; Sandra Sousa; Isabel Pereira; Maria Graça Pinto; Sónia Correia; Josvany Sánchez-Curbelo; Olga López-Rodrigo; Javier Martín; Iris Pereira-Caetano; Patricia I. Marques; Filipa Carvalho; Alberto Barros; Jörg Gromoll; Lluís Bassas; Susana Seixas; João Gonçalves; Sara Larriba; Sabine Kliesch; Rogelio J. Palomino-Morales; F. David Carmona
Source
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
A GWAS in a large case-control cohort of European ancestry identifies two genomic regions, the MHC class II gene HLA-DRB1 and an upstream locus of VRK1, that are associated with the most severe phenotype of spermatogenic failure.