학술논문
葡萄糖转运蛋白4在鱼类糖代谢中的作用研究进展 / Research Progress on Glucose Transporter 4 in Glucose Metabolism in Fish:a Review
Document Type
Academic Journal
Author
Source
水产学杂志 / Chinese Journal of Fisheries. 36(5):138-147
Subject
Language
Chinese
ISSN
1005-3832
Abstract
葡萄糖转运蛋白4(GLUT4)可直接促进细胞对葡萄糖的吸收,在机体糖代谢中占有重要地位.哺乳动物的GLUT4主要在骨骼肌和脂肪组织表达,其转运调控作用有较为系统的研究.GLUT4参与磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、单磷酸腺苷活化蛋白激酶(AMPK)和蛋白激酶C(PKC)等与糖代谢有关的信号通路.自在鱼类中GLUT4发现以来,已证实其与哺乳动物具有较高的同源性,而鱼类GLUT4的结构和转运方式与哺乳动物不同.初步探究了胰岛素依赖途径影响鱼类葡萄糖的吸收机理.已证实,AMPK作为非胰岛素依赖性葡萄糖转运途径的重要因素,也影响鱼体葡萄糖的吸收进程.然而,目前PKC信号通路涉及到鱼类GLUT4介导的葡萄糖代谢还未见报道.探究鱼类糖代谢机制一直是鱼类营养学代谢研究的焦点之一.本文从以上三个调控转运葡萄糖的信号通路入手,阐述GLUT4在鱼类中的研究进展,以期为深入探讨鱼类糖代谢机制提供相应的理论依据.
Glucose transporter 4(GLUT4)directly promoted the absorption of glucose by cells and plays a vital role in glucose metabolism.In mammals,GLUT4 is mainly expressed in skeletal muscle and adipose tissue,and had been systematically research on the mechanism of regulation of the GLUT4 transport function.It has been reported that GLUT4 is involved in signal pathways related to carbohydrate metabolism,including phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),AMP-activated protein kinase(AMPK),and protein kinase C(PKC).Since the GLUT4 is found in fish,it had been confirmed that GLUT4 in fish had high homolo-gy with mammals,with different structure and transport mode from those of mammals.The effect of insulin-dependent pathway on glucose absorption in fish was preliminarily explored.AMPK,as an important factor in the non-insulin-dependent glucose transport pathway,had been shown to affect the glucose absorption process in fish.However,PKC signaling pathway was not involved in GLUT4-mediated glucose metabolism in fish.Exploring the mechanism of glucose metabolism in fish has always been the hotspot of fish nutrition.This review would focus on the above three signal pathways by which regulate the transportation of glucose,summarizes the research on GLUT4 in fish,and provides the corresponding theoretical basis for further research of the mechanism of glucose metabolism in fish.
Glucose transporter 4(GLUT4)directly promoted the absorption of glucose by cells and plays a vital role in glucose metabolism.In mammals,GLUT4 is mainly expressed in skeletal muscle and adipose tissue,and had been systematically research on the mechanism of regulation of the GLUT4 transport function.It has been reported that GLUT4 is involved in signal pathways related to carbohydrate metabolism,including phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),AMP-activated protein kinase(AMPK),and protein kinase C(PKC).Since the GLUT4 is found in fish,it had been confirmed that GLUT4 in fish had high homolo-gy with mammals,with different structure and transport mode from those of mammals.The effect of insulin-dependent pathway on glucose absorption in fish was preliminarily explored.AMPK,as an important factor in the non-insulin-dependent glucose transport pathway,had been shown to affect the glucose absorption process in fish.However,PKC signaling pathway was not involved in GLUT4-mediated glucose metabolism in fish.Exploring the mechanism of glucose metabolism in fish has always been the hotspot of fish nutrition.This review would focus on the above three signal pathways by which regulate the transportation of glucose,summarizes the research on GLUT4 in fish,and provides the corresponding theoretical basis for further research of the mechanism of glucose metabolism in fish.