학술논문
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Document Type
Article
Author
Bentley, Amy R.; Sung, Yun J.; Brown, Michael R.; Winkler, Thomas W.; Kraja, Aldi T.; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I.; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Baker, Jenna; Chen, Guanjie; Aschard, Hugues; Bartz, Traci M.; Ding, Jingzhong; Dorajoo, Rajkumar; Manning, Alisa K.; Rankinen, Tuomo; Smith, Albert V.; Tajuddin, Salman M.; Zhao, Wei; Graff, Mariaelisa; Alver, Maris; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Goel, Anuj; Hagemeijer, Yanick; Harris, Sarah E.; Hartwig, Fernando P.; He, Meian; Horimoto, Andrea R. V. R.; Hsu, Fang-Chi; Hung, Yi-Jen; Jackson, Anne U.; Kasturiratne, Anuradhani; Komulainen, Pirjo; Kühnel, Brigitte; Leander, Karin; Lin, Keng-Hung; Luan, Jian’an; Lyytikäinen, Leo-Pekka; Matoba, Nana; Nolte, Ilja M.; Pietzner, Maik; Prins, Bram; Riaz, Muhammad; Robino, Antonietta; Said, M. Abdullah; Schupf, Nicole; Scott, Robert A.; Sofer, Tamar; Stancáková, Alena; Takeuchi, Fumihiko; Tayo, Bamidele O.; van der Most, Peter J.; Varga, Tibor V.; Wang, Tzung-Dau; Wang, Yajuan; Ware, Erin B.; Wen, Wanqing; Xiang, Yong-Bing; Yanek, Lisa R.; Zhang, Weihua; Zhao, Jing Hua; Adeyemo, Adebowale; Afaq, Saima; Amin, Najaf; Amini, Marzyeh; Arking, Dan E.; Arzumanyan, Zorayr; Aung, Tin; Ballantyne, Christie; Barr, R. Graham; Bielak, Lawrence F.; Boerwinkle, Eric; Bottinger, Erwin P.; Broeckel, Ulrich; Brown, Morris; Cade, Brian E.; Campbell, Archie; Canouil, Mickaël; Charumathi, Sabanayagam; Chen, Yii-Der Ida; Christensen, Kaare; Concas, Maria Pina; Connell, John M.; de las Fuentes, Lisa; de Silva, H. Janaka; de Vries, Paul S.; Doumatey, Ayo; Duan, Qing; Eaton, Charles B.; Eppinga, Ruben N.; Faul, Jessica D.; Floyd, James S.; Forouhi, Nita G.; Forrester, Terrence; Friedlander, Yechiel; Gandin, Ilaria; Gao, He; Ghanbari, Mohsen; Gharib, Sina A.; Gigante, Bruna; Giulianini, Franco; Grabe, Hans J.; Gu, C. Charles; Harris, Tamara B.; Heikkinen, Sami; Heng, Chew-Kiat; Hirata, Makoto; Hixson, James E.; Ikram, M. Arfan; Jia, Yucheng; Joehanes, Roby; Johnson, Craig; Jonas, Jost Bruno; Justice, Anne E.; Katsuya, Tomohiro; Khor, Chiea Chuen; Kilpeläinen, Tuomas O.; Koh, Woon-Puay; Kolcic, Ivana; Kooperberg, Charles; Krieger, Jose E.; Kritchevsky, Stephen B.; Kubo, Michiaki; Kuusisto, Johanna; Lakka, Timo A.; Langefeld, Carl D.; Langenberg, Claudia; Launer, Lenore J.; Lehne, Benjamin; Lewis, Cora E.; Li, Yize; Liang, Jingjing; Lin, Shiow; Liu, Ching-Ti; Liu, Jianjun; Liu, Kiang; Loh, Marie; Lohman, Kurt K.; Louie, Tin; Luzzi, Anna; Mägi, Reedik; Mahajan, Anubha; Manichaikul, Ani W.; McKenzie, Colin A.; Meitinger, Thomas; Metspalu, Andres; Milaneschi, Yuri; Milani, Lili; Mohlke, Karen L.; Momozawa, Yukihide; Morris, Andrew P.; Murray, Alison D.; Nalls, Mike A.; Nauck, Matthias; Nelson, Christopher P.; North, Kari E.; O’Connell, Jeffrey R.; Palmer, Nicholette D.; Papanicolau, George J.; Pedersen, Nancy L.; Peters, Annette; Peyser, Patricia A.; Polasek, Ozren; Poulter, Neil; Raitakari, Olli T.; Reiner, Alex P.; Renström, Frida; Rice, Treva K.; Rich, Stephen S.; Robinson, Jennifer G.; Rose, Lynda M.; Rosendaal, Frits R.; Rudan, Igor; Schmidt, Carsten O.; Schreiner, Pamela J.; Scott, William R.; Sever, Peter; Shi, Yuan; Sidney, Stephen; Sims, Mario; Smith, Jennifer A.; Snieder, Harold; Starr, John M.; Strauch, Konstantin; Stringham, Heather M.; Tan, Nicholas Y. Q.; Tang, Hua; Taylor, Kent D.; Teo, Yik Ying; Tham, Yih Chung; Tiemeier, Henning; Turner, Stephen T.; Uitterlinden, André G.; van Heemst, Diana; Waldenberger, Melanie; Wang, Heming; Wang, Lan; Wang, Lihua; Wei, Wen Bin; Williams, Christine A.; Wilson, Gregory; Wojczynski, Mary K.; Yao, Jie; Young, Kristin; Yu, Caizheng; Yuan, Jian-Min; Zhou, Jie; Zonderman, Alan B.; Becker, Diane M.; Boehnke, Michael; Bowden, Donald W.; Chambers, John C.; Cooper, Richard S.; de Faire, Ulf; Deary, Ian J.; Elliott, Paul; Esko, Tõnu; Farrall, Martin; Franks, Paul W.; Freedman, Barry I.; Froguel, Philippe; Gasparini, Paolo; Gieger, Christian; Horta, Bernardo L.; Juang, Jyh-Ming Jimmy; Kamatani, Yoichiro; Kammerer, Candace M.; Kato, Norihiro; Kooner, Jaspal S.; Laakso, Markku; Laurie, Cathy C.; Lee, I-Te; Lehtimäki, Terho; Magnusson, Patrik K. E.; Oldehinkel, Albertine J.; Penninx, Brenda W. J. H.; Pereira, Alexandre C.; Rauramaa, Rainer; Redline, Susan; Samani, Nilesh J.; Scott, James; Shu, Xiao-Ou; van der Harst, Pim; Wagenknecht, Lynne E.; Wang, Jun-Sing; Wang, Ya Xing; Wareham, Nicholas J.; Watkins, Hugh; Weir, David R.; Wickremasinghe, Ananda R.; Wu, Tangchun; Zeggini, Eleftheria; Zheng, Wei; Bouchard, Claude; Evans, Michele K.; Gudnason, Vilmundur; Kardia, Sharon L. R.; Liu, Yongmei; Psaty, Bruce M.; Ridker, Paul M.; van Dam, Rob M.; Mook-Kanamori, Dennis O.; Fornage, Myriam; Province, Michael A.; Kelly, Tanika N.; Fox, Ervin R.; Hayward, Caroline; van Duijn, Cornelia M.; Tai, E. Shyong; Wong, Tien Yin; Loos, Ruth J. F.; Franceschini, Nora; Rotter, Jerome I.; Zhu, Xiaofeng; Bierut, Laura J.; Gauderman, W. James; Rice, Kenneth; Munroe, Patricia B.; Morrison, Alanna C.; Rao, Dabeeru C.; Rotimi, Charles N.; Cupples, L. Adrienne
Source
Nature Genetics; April 2019, Vol. 51 Issue: 4 p636-648, 13p
Subject
Language
ISSN
10614036; 15461718
Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.