학술논문
Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial
Document Type
Article
Author
Post, René; Germans, Menno R; Tjerkstra, Maud A; Vergouwen, Mervyn D I; Jellema, Korné; Koot, Radboud W; Kruyt, Nyika D; Willems, Peter W A; Wolfs, Jasper F C; de Beer, Frits C; Kieft, Hans; Nanda, Dharmin; van der Pol, Bram; Roks, Gerwin; de Beer, Frank; Halkes, Patricia H A; Reichman, Loes J A; Brouwers, Paul J A M; van den Berg-Vos, Renske M; Kwa, Vincent I H; van der Ree, Taco C; Bronner, Irene; van de Vlekkert, Janneke; Bienfait, Henri P; Boogaarts, Hieronymus D; Klijn, Catharina J M; van den Berg, René; Coert, Bert A; Horn, Janneke; Majoie, Charles B L M; Rinkel, Gabriël J E; Roos, Yvo B W E M; Vandertop, W Peter; Verbaan, Dagmar; Post, René; Germans, Menno R.; Tjerkstra, Maud A.; Vergouwen, Mervyn D.I.; Jellema, Korné; Koot, Radboud W.; Kruyt, Nyika D.; Willems, Peter W.A.; Wolfs, Jasper F.C.; de Beer, Frits C.; Kieft, Hans; Nanda, Dharmin; van der Pol, Bram; Roks, Gerwin; de Beer, Frank; Halkes, Patricia H.A.; Reichman, Loes J.A.; Brouwers, Paul J.A.M.; van den Berg-Vos, Renske M.; Kwa, Vincent I.H.; van der Ree, Taco C.; Bronner, Irene; Bienfait, Henri P.; Boogaarts, Hieronymus D.; Klijn, Catharina J.M.; van Bilzen, Martine; Dieks, H.J.G.; de Gans, Koen; ten Holter, J.B.M.; de Kruijk, Jelle R.; Leijzer, Charlie T.J.M.; Molenaar, Delmar; van Oostenbrugge, Robbert J.; van Pamelen, Jeske; Spaander, Fianne H.M.; Vermeer, Sarah E.; van de Vlekkert, Janneke; Voorend, J. Manuela; van den Berg, René; Coert, Bert A.; Horn, Janneke; Majoie, Charles B.L.M.; Rinkel, Gabriël J.E.; Roos, Yvo B.W.E.M.; Vandertop, W. Peter; Verbaan, Dagmar
Source
The Lancet; January 2021, Vol. 397 Issue: 10269 p112-118, 7p
Subject
Language
ISSN
01406736; 1474547X
Abstract
In patients with aneurysmal subarachnoid haemorrhage, short-term antifibrinolytic therapy with tranexamic acid has been shown to reduce the risk of rebleeding. However, whether this treatment improves clinical outcome is unclear. We investigated whether ultra-early, short-term treatment with tranexamic acid improves clinical outcome at 6 months.