학술논문
Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns)
Document Type
Article
Author
Stocker, Martin; van Herk, Wendy; el Helou, Salhab; Dutta, Sourabh; Fontana, Matteo S; Schuerman, Frank A B A; van den Tooren-de Groot, Rita K; Wieringa, Jantien W; Janota, Jan; van der Meer-Kappelle, Laura H; Moonen, Rob; Sie, Sintha D; de Vries, Esther; Donker, Albertine E; Zimmerman, Urs; Schlapbach, Luregn J; de Mol, Amerik C; Hoffman-Haringsma, Angelique; Roy, Madan; Tomaske, Maren; Kornelisse, René F; van Gijsel, Juliette; Visser, Eline G; Willemsen, Sten P; van Rossum, Annemarie M C; Bakry, A; Dutta, S; el Helou, S; Kalaniti, K; Pogorzelski, D; Alliston, S; Roy, M; Grey, V; Hauff, K; Hill, S; Kittanakom, S; Janota, J; Visnovska, M; Fontana, M; Lanz, N; Stocker, M; Glauser, D; Zimmerman, U; Tomaske, M; Nelle, M; Schlapbach, LJ; Schuerman, FABA; Sie, SD; van Weissenbruch, MM; van den Dungen, FAM; Strik, M; van den Tooren-de, HK; van Rossum, Groot A; Batstra, M; van der Meer-Kappelle, LH; de Vries, E; de Mol, AC; Bolt-Wieringa, J; Stok, Daniel; Moonen, R; Donker, S; van Gijsel, J; Gondriet, IPE; van Herk, W; Hoekstein, S; Hofhuis, M; Hop, W; de Ligt, L; Manai, B; Kornelisse, R; de Rijke, Y; van Rossum, A; Siiskonen, S; van der Velden, J; Visser, EG; van Wijk, J Asch; Willemsen, S; van der Geijn, GJ; Haringsma, A; Andriessen, PA; Broeren, MAC; Donker, A
Source
The Lancet; August-September 2017, Vol. 390 Issue: 10097 p871-881, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Up to 7% of term and late-preterm neonates in high-income countries receive antibiotics during the first 3 days of life because of suspected early-onset sepsis. The prevalence of culture-proven early-onset sepsis is 0·1% or less in high-income countries, suggesting substantial overtreatment. We assess whether procalcitonin-guided decision making for suspected early-onset sepsis can safely reduce the duration of antibiotic treatment.