학술논문
A lineage-specific STAT5BN642Hmouse model to study NK-cell leukemia
Document Type
Article
Author
Klein, Klara; Kollmann, Sebastian; Hiesinger, Angela; List, Julia; Kendler, Jonatan; Klampfl, Thorsten; Rhandawa, Mehak; Trifinopoulos, Jana; Maurer, Barbara; Grausenburger, Reinhard; Betram, Christof A.; Moriggl, Richard; Rülicke, Thomas; Mullighan, Charles G.; Witalisz-Siepracka, Agnieszka; Walter, Wencke; Hoermann, Gregor; Sexl, Veronika; Gotthardt, Dagmar
Source
Blood; June 2024, Vol. 143 Issue: 24 p2474-2489, 16p
Subject
Language
ISSN
00064971; 15280020
Abstract
•Generation of a lineage-specific STAT5BN642Htransgenic mouse model that develops NK-cell leukemia.•Leukemic NK cells with a STAT5Bgain-of-function mutation share a unique transcriptional profile in mice and human patients.