학술논문
Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial
Document Type
Article
Author
von Herrath, Matthias; Bain, Stephen C; Bode, Bruce; Clausen, Jesper Ole; Coppieters, Ken; Gaysina, Leylya; Gumprecht, Janusz; Hansen, Troels Krarup; Mathieu, Chantal; Morales, Cristobal; Mosenzon, Ofri; Segel, Stine; Tsoukas, George; Pieber, Thomas R; Ludvik, Bernhard; Prager, Rudolf; Paulweber, Bernhard; Ebenbichler, Christoph F; Keymeulen, B; De Block, C; Grossman, Loren; Houlden, Robyn; Perron, Patrice; Ransom, Thomas; Senior, Peter; Weisnagel, S. John; Woo, Vincent; Dumas, Richard; Thompson, David; Vilsbøll, Tina; Gram, Jeppe; Juhl, Claus Bogh; Hukkanen, Janne; Lahtela, Jorma; Niskanen, Leo; O'Shea, Donal; O'Brien, Timothy; Sreenan, Seamus; Wainstein, Julio; Phillip, Moshe; Knobler, Hilla; Dotta, Francesco; Piatti, Pier Marco; Roberto, Trevisan; Gnasso, Agostino; Gulseth, Hanne; Cooper, John; Pankowska, Ewa; Lukaszewicz, Monika; Wolnik, Bogumił; Manita, Isabel; Marques, Olinda; Roque, Cristina; Príncipe, Rosa Maria; Neves, Celestino; Heitor, Susana; Ruyatkina, L; Dvoryashina, Irina; Vagapova, Gulnar; Belousova, Lidiya; Sergeeva-Kondrachenko, Marina; Peskov, Andrey; Frolova, Elena; Golovach, Albina; Kunitsyna, Marina; Krasnopeeva (Kabachkova), Natalia; Ipatko, Irina; De la Cuesta, Carmen; Tinahones, Francisco José; Rigla, Mercedes; Merino, Juan Francisco; Gómez, Luis Alberto; Fernández, Mercè; Simó, Rafael; Rydén, Mikael; Jendle, Johan; Filipsson, Karin; Eliasson, Björn; Mankovsky, Borys; Lymar, Iurii; Sokolova, Liubov; Myshanych, Galyna; Zlova, Tetiana; Vlasenko, Maryna; Kuskalo -, Petro; Courtney, Hamish; Dayan, Colin; English, Patrick; Heller, Simon; Johnson, Andrew B; Nair, Sunil; Leslie, R. D; Narendran, P; Oliver, Nick; Ramtoola, Shenaz; Shaw, Jim; Viljoen -, Adie; Al-Karadsheh, Amer; Dostou, Jean Marie; Gangi, Sumana; Gottlieb, Peter; Jerkins, Terri; Magnotti, Michael; Marks, Jennifer; Nakhle, Samer; Bonabi, Gholamreza; Myers, Lyle; Pratley, Richard; Hagopian, William; Pettus, Jeremy; von Scholten, Bernt Johan; Wesley, Johnna D; Kreiner, Frederik F
Source
The Lancet Diabetes & Endocrinology; April 2021, Vol. 9 Issue: 4 p212-224, 13p
Subject
Language
ISSN
22138587; 22138595
Abstract
Type 1 diabetes is characterised by progressive loss of functional β-cell mass, necessitating insulin treatment. We aimed to investigate the hypothesis that combining anti-interleukin (IL)-21 antibody (for low-grade and transient immunomodulation) with liraglutide (to improve β-cell function) could enable β-cell survival with a reduced risk of complications compared with traditional immunomodulation.