학술논문
Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+ T Cells Requires the Presence of Cognate Antigen
Document Type
Article
Author
Source
Infection and Immunity; January 2006, Vol. 74 Issue: 1 p773-776, 4p
Subject
Language
ISSN
00199567; 10985522
Abstract
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.