학술논문
Blood CD9+B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation
Document Type
Article
Author
Brosseau, Carole; Danger, Richard; Durand, Maxim; Durand, Eugénie; Foureau, Aurore; Lacoste, Philippe; Tissot, Adrien; Roux, Antoine; Reynaud‐Gaubert, Martine; Kessler, Romain; Mussot, Sacha; Dromer, Claire; Brugière, Olivier; Mornex, Jean François; Guillemain, Romain; Claustre, Johanna; Magnan, Antoine; Brouard, Sophie; Jougon, J.; Velly, J.‐F.; Rozé, H.; Blanchard, E.; Antoine, M.; Cappello, M.; Ruiz, M.; Sokolow, Y.; Vanden Eynden, F; Van Nooten, G.; Barvais, L.; Berré, J.; Brimioulle, S.; De Backer, D.; Créteur, J.; Engelman, E; Huybrechts, I.; Ickx, B.; Preiser, T.J.C.; Tuna, T.; Van Obberghe, L.; Vancutsem, N.; Vincent, J.‐L.; De Vuyst, P.; Etienne, I.; Féry, F.; Jacobs, F.; Knoop, C.; Vachiéry, J.L.; Van den Borne, P.; Wellemans, I.; Amand, G.; Collignon, L.; Giroux, M.; Angelescu, D.; Chavanon, O.; Hacini, R.; Martin, C.; Pirvu, A.; Porcu, P.; Albaladejo, P.; Allègre, C.; Bataillard, A.; Bedague, D.; Briot, E.; Casez‐Brasseur, M.; Colas, D.; Dessertaine, G.; Francony, G.; Hebrard, A.; Marino, M.R.; Protar, D.; Rehm, D.; Robin, S; Rossi‐Blancher, M.; Augier, C.; Bedouch, P.; Boignard, A.; Bouvaist, H.; Briault, A.; Camara, B.; Chanoine, S.; Dubuc, M.; Quétant, S.; Maurizi, J.; Pavèse, P.; Pison, C.; Saint‐Raymond, C.; Wion, N.; Chérion, C.; Grima, R.; Jegaden, O.; Maury, J.‐M.; Tronc, F.; Flamens, C.; Paulus, S.; Philit, F.; Senechal, A.; Glérant, J.‐C.; Turquier, S.; Gamondes, D.; Chalabresse, L.; Thivolet‐Bejui, F.; Barnel, C.; Dubois, C.; Tiberghien, A.; Pimpec‐Barthes, F.; Bel, A.; Mordant, P.; Achouh, P.; Boussaud, V.; Méléard, D.; Bricourt, M.O.; Cholley, B.; Pezella, V.; Brioude, G.; D'Journo, X.B.; Doddoli, C.; Thomas, P.; Trousse, D.; Dizier, S.; Leone, M.; Papazian, L.; Bregeon, F.; Coltey, B.; Dufeu, N.; Dutau, H.; Garcia, S.; Gaubert, J.Y.; Gomez, C.; Laroumagne, S.; Mouton, G.; Nieves, A.; Picard, Ch.; Rolain, J.M.; Sampol, E.; Secq, V.; Perigaud, C.; Roussel, J.C.; Senage, T.; Mugniot, A.; Danner, I.; Haloun, A.; Abbes, S.; Bry, C.; Blanc, F.X.; Lepoivre, T.; Botturi‐Cavaillès, K.; Loy, J.; Bernard, M.; Godard, E.; Royer, P.‐J.; Henrio, K.; Dartevelle, Ph.; Fabre, D.; Fadel, E.; Mercier, O.; Stephan, F.; Viard, P.; Cerrina, J.; Dorfmuller, P.; Feuillet, S.; Ghigna, M.; Hervén, Ph.; Le Roy Ladurie, F.; Le Pavec, J.; Thomas de Montpreville, V.; Lamrani, L.; Castier, Y.; Mordant, P.; Cerceau, P.; Augustin, P.; Jean‐Baptiste, S.; Boudinet, S.; Montravers, P.; Dauriat, G.; Jébrak, G.; Mal, H.; Marceau, A.; Métivier, A.‐C.; Thabut, G.; Lhuillier, E.; Dupin, C.; Bunel, V.; Falcoz, P.; Massard, G.; Santelmo, N.; Ajob, G.; Collange, O.; Helms, O.; Hentz, J.; Roche, A.; Bakouboula, B.; Degot, T.; Dory, A.; Hirschi, S.; Ohlmann‐Caillard, S.; Kessler, L.; Schuller, A.; Bennedif, K.; Vargas, S.; Bonnette, P.; Chapelier, A.; Puyo, P.; Sage, E.; Bresson, J.; Caille, V.; Cerf, C.; Devaquet, J.; Dumans‐Nizard, V.; Felten, M.L.; Fischler, M.; Si Larbi, A.G.; Leguen, M.; Ley, L.; Liu, N.; Trebbia, G.; De Miranda, S.; Douvry, B.; Gonin, F.; Grenet, D.; Hamid, A.M.; Neveu, H.; Parquin, F.; Picard, C.; Stern, M.; Bouillioud, F.; Cahen, P.; Colombat, M.; Dautricourt, C.; Delahousse, M.; D'Urso, B.; Gravisse, J.; Guth, A.; Hillaire, S.; Honderlick, P.; Lequintrec, M.; Longchampt, E.; Mellot, F.; Scherrer, A.; Temagoult, L.; Tricot, L.; Vasse, M.; Veyrie, C.; Zemoura, L.; Dahan, M.; Murris, M.; Benahoua, H.; Berjaud, J.; Le Borgne Krams, A.; Crognier, L.; Brouchet, L.; Mathe, O.; Didier, A.; Krueger, T.; Ris, H.B.; Gonzalez, M.; Aubert, J.‐D.; Nicod, L.P.; Marsland, B.J.; Berutto, T.C.; Rochat, T.; Soccal, P.; Jolliet, Ph.; Koutsokera, A.; Marcucci, C.; Manuel, O.; Bernasconi, E.; Chollet, M.; Gronchi, F.; Courbon, C.; Hillinger, S.; Inci, I.; Kestenholz, P.; Weder, W.; Schuepbach, R.; Zalunardo, M.; Benden, C.; Buergi, U.; Huber, L.C.; Isenring, B.; Schuurmans, M.M.; Gaspert, A.; Holzmann, D.; Müller, N.; Schmid, C.; Vrugt, B.; Rechsteiner, T.; Fritz, A.; Maier, D.; Deplanche, K.; Koubi, D.; Ernst, F.; Paprotka, T.; Schmitt, M.; Wahl, B.; Boissel, J.‐P.; Olivera‐Botello, G.; Trocmé, C.; Toussaint, B.; Bourgoin‐Voillard, S.; Séve, M.; Benmerad, M.; Siroux, V.; Slama, R.; Auffray, C.; Charron, D.; Lefaudeux, D.; Pellet, J.
Source
American Journal of Transplantation; November 2019, Vol. 19 Issue: 11 p3162-3175, 14p
Subject
Language
ISSN
16006135; 16006143
Abstract
Bronchiolitis obliterans syndrome is the main limitation for long‐term survival after lung transplantation. Some specific B cell populations are associated with long‐term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up. CD24hiCD38hitransitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hiCD38hitransitional B cells specifically secrete IL‐10 and express CD9. Thus, patients with a total CD9+B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL‐10‐secreting CD24hiCD38hitransitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9‐expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long‐term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival. In lung transplant patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow‐up, IL‐10–secreting CD24hiCD38hi transitional B cells expressing CD9 are associated with better allograft outcome, suggesting CD9‐expressing B cells as a new predictive biomarker of bronchiolitis obliterans syndrome–free survival.