학술논문
Chiral β-amino sulfoxides. Synthesis, configurational assignment and conformational analysis based on X-ray, CD, 1H NMR and theoretical calculations
Document Type
Article
Author
Source
Tetrahedron; June 1998, Vol. 54 Issue: 23 p6571-6586, 16p
Subject
Language
ISSN
00404020
Abstract
Enantiomerically pure uand lβ-amino sulfoxides have been easily obtained from the respective homochiral α-amino alcohols. The absolute configuration at the created stereogenic centre was assigned by CD spectra and by X-ray analysis. Conformational analysis of the title compounds was carried out using quantum chemical energy-geometry optimization. Thus established conformational behavior explained the strongly configuration dependent NMR spectral patterns observed for the uand ldiastereomers.