학술논문

Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial
Document Type
Article
Author
Anderson, Craig SHuang, YiningLindley, Richard IChen, XiaoyingArima, HisatomiChen, GuofangLi, QiangBillot, LaurentDelcourt, CandiceBath, Philip MBroderick, Joseph PDemchuk, Andrew MDonnan, Geoffrey ADurham, Alice CLavados, Pablo MLee, Tsong-HaiLevi, ChristopherMartins, Sheila OOlavarria, Veronica VPandian, Jeyaraj DParsons, Mark WPontes-Neto, Octavio MRicci, StefanoSato, ShoichiroSharma, Vijay KSilva, FedericoSong, LiliThang, Nguyen HWardlaw, Joanna MWang, Ji-GuangWang, XiaWoodward, MarkChalmers, JohnRobinson, Thompson GAnderson, Craig S.Huang, YiningLindley, Richard I.Chen, XiaoyingArima, HisatomiChen, GuofangLi, QiangBillot, LaurentDelcourt, CandiceBath, Philip M.Broderick, Joseph P.Demchuk, Andrew M.Donnan, Geoffrey A.Durham, Alice C.Lavados, Pablo M.Lee, Tsong-HaiLevi, ChristopherMartins, Sheila O.Olavarria, Veronica V.Pandian, Jeyaraj D.Parsons, Mark W.Pontes-Neto, Octavio M.Ricci, StefanoSato, ShoichiroSharma, Vijay K.Silva, FedericoSong, LiliThang, Nguyen H.Wardlaw, Joanna M.Wang, Ji-GuangWang, XiaWoodward, MarkChalmers, JohnRobinson, Thompson G.Kim, Jong S.Stapf, ChristianSimes, R. JohnHankey, Graeme J.Sandercock, PeterBousser, Marie-GermaineWong, K.S. LawrenceScaria, AnishHirakawa, YoichiroMoullaali, Tom J.Carcel, CherylGordon, PennyFuentes-Patarroyo, Sully X.Benito, DinoChen, RuiqiCao, YongjunKunchok, AmyWinters, StephenCoutts, ShelaghYoshimura, SoheiYou, ShoujiangYang, JieWu, GuojunZhang, ShihongManning, LisaMistri, AmitHaunton, VictoriaMinhas, JatinderMalavera, AlejandraLim, JoyceLiu, LeiboKumar, Namrata N.Tay, NicoleJenson, KerryRichtering, SarahTucker, SharonKnight, ElizabethIvanova, ElizavetaThembani, EmmaOdgers, ElizabethSanders, ElizabethSmall, SabrinaVaghasiya, RuchitaArmenis, ManuelaDonnelly, PaulBaig, Merza A.Blacklock, NickNaidu, BalaMonaghan, HelenSmith, PhillipaGlass, ParisaBai, XuejieLi, QianchengZhu, PingpingKong, LiangHe, RuihongZhao, HeLv, JiajieJia, HaijingXi, ZhenCong, YuhanCui, BuliangDeng, HuaGuo, YingHe, LingyuJia, RuolanLi, NanLi, WeiLiu, MengxiaoZhang, MengXu, ZiweiZhang, TingZhao, YanGregory, PhilipIn, YunjeongKim, Su J.Ahn, Jung E.Kim, Sul H.Hong, Young L.González-McCawley, FranciscaMartins, Magda C.O.Portales, BernarditaWang, Ching-YiRyu, Shan-JenAujla, HardeepLewin, SueKumar, TracyBarrows, SaraEbraimo, AhtasamUyen, Hong H.Giang, Nguyen A.Linh, Le T.M.An, Le T.T.Phuong, Do M.Ngoc, Pham V.B.Hang, Nguyen M.Tran, Nguyen T.B.Hien, Ha T.T.Yen, Mai B.Tram, Ngo T.B.Truc, Tran T.T.Hoa, Nguyen A.Thuan, Nguyen T.B.Oanh, Ha T.K.Arora, DeeptiVerma, Shweta J.Krause, M.Priglinger, M.Day, S.Jala, S.Davies, L.Ray, E.Celestino, S.Law, L.Y.Wijeratne, T.Ng, G.Nagao, K.Weiss, G.Titton, N.Batista, C.Zãn, D.Carbonera, L.Ferreira, K.Castro, R.Martins Filho, R.K.Carvalho, M.Libardi, M.Martins, G.Fagundes, D.Baron, G.Boehringer, A.Barbosa, J.Bazan, R.Braga, G.Luvizutto, G.Ribeiro, P.Winckler, F.Moro, C.Longo, A.Liberato, R.Barbosa, R.Magalhães, P.Portal, M.Martin, K.Souza, A.Cuervo, D.Perin, D.Marques, L.Oliveira, F.Battaglini, M.Lourenço, F.Ferreira, K.Silva, G.Duarte, L.Alves, M.Sousa, J.Uhehara, M.Brunser, A.Mazzón, E.Spencer, M.Acosta, I.Rojo, A.Rivas, R.Klapp, C.Carvallo, L.Carvallo, P.Mansilla, E.Flores, J.Alvarado, M.Herrera, A.Reyes, C.Jurado, F.Bustamante, G.Bravo, L.Matamala, J.M.Guerrero, R.Zhou, S.Ping, L.Liu, W.Liu, L.Tian, Y.Xu, H.Wang, J.Wang, L.Zhen, Z.Wang, L.Zhang, J.Yan, M.Wang, L.Zhang, Q.Tao, X.Liu, C.Shi, J.Zhang, X.Tai, L.Xu, L.Lu, H.Nie, H.Li, X.Zhou, J.Liu, Y.Gong, P.Tian, Y.Zhao, H.Zhang, J.Li, R.Wang, X.Chen, Q.Li, Y.Wu, L.Zhang, J.Jia, L.Guo, X.Li, X.Chen, G.Lin, B.Zhu, W.Yang, K.Zhang, J.Zhang, Z.Xie, C.Wu, D.Zhang, Z.Li, X.Wang, Y.Liu, D.Liu, Z.Liang, L.Cao, Q.Zhang, X.Xia, J.Li, X.Weng, Y.Li, J.Xu, T.Geng, D.Yan, X.Wang, D.Zhao, N.Li, J.Wang, D.Tang, Z.Wang, L.Yin, W.Wang, S.Wang, D.Huang, W.Yang, Y.Song, A.Hao, Y.Zhang, A.Qiao, B.Yang, J.Yan, H.Wei, X.Tao, Z.Liu, H.Lv, Y.Yang, H.Han, L.Mao, X.Ge, L.Zhang, Y.He, S.Zhang, Q.Zhao, H.Jiang, J.Yan, M.Liu, D.Wu, W.Wang, H.Wang, Y.Yang, L.Tang, Y.Sun, H.Li, F.Li, G.Sun, Y.Zhang, H.Wu, Y.Huang, L.Geng, C.Jin, Z.Zhu, J.Zhang, F.Zhang, Y.Zhang, Z.Zheng, R.Shen, H.Liu, F.Chen, C.Li, G.Chen, S.Zhou, L.Hu, B.Zou, Z.Liu, J.Zhang, X.Chang, X.Wang, D.Zhang, S.Huang, Q.Liu, X.Liu, S.He, W.Feng, J.Li, L.Chen, X.Zhuang, X.Liu, Y.Zheng, W.Lai, Y.Zhou, Y.Duan, H.Cao, Q.Yang, Q.Du, J.Lin, QXu, E.Zhan, L.Yang, L.Huang, Q.Wu, J.Feng, X.Wei, C.He, J.Wang, B.Liu, X.Li, WChen, PGuo, FDai, HDai, MZeng, X.Wang, D.Chen, B.Long, F.Su, Q.Wang, Y.Bao, B.Wu, T.Wu, X.Shao, Y.Nie, H.Zhang, X.Li, S.Xu, Y.Castellanos, J.A.Muñoz-Collazos, M.Solano, E.Leung, W.H.T.Sureshbabu, S.Sharma, S.N.George, S.Shekhar, S.Singla, S.Saini, L.Sunita, -Kate, M.Sarvotham, R.William, A.G.Deepak, A.BK, M.Benny, R.Bolegave, V.Basle, M.Gore, S.George, P.Kumaravelu, S.Rahamath, S.Raj, P.G.Devi, A.R.Sharma, A.Prajapati, J.Parmar, M.Patel, D.Panchal, T.Gorthi, S.P.Prabhu, V.Prabhu, A.Chandran, V.Chatterjee, A.Nair, R.Nambiar, V.K.TS, D.TP, S.Ajai, V.Paul, S.Natarajan, P.C.Chittibabu, D.Borah, N.C.Ghose, M.Choudhury, N.Gohain, P.Kalita, K.Duberkar, D.Pawar, N.Bhaviskar, R.Caterbi, E.Cenciarelli, S.Condurso, R.Gallinella, E.Greco, L.Marando, C.Mastrocola, S.Mattioni, A.Sacchini, E.Sicilia, I.Gallina, A.Giannandrea, D.Marsili, E.Mazzoli, T.Padiglioni, C.Corea, F.Guidubaldi, A.Micheli, S.Barbi, M.Kim, J.Song, H.J.Jeong, H.S.Lim, J.G.Park, S.M.Lee, K.B.Hwang, H.W.Kwon, S.U.Kang, D.W.Kim, Y.J.Kim, B.J.Park, J.M.Kang, K.Kim, B.Kwon, O.Kim, Y.W.Lee, J.J.Hwang, Y.H.Kwon, H.S.Koo, J.Lee, K.Kim, T.Ahn, A.Rha, J.H.Park, H.K.Yoon, C.W.Chan, B.Teoh, H.L.Paliwal, P.Wong, L.Y.J.Chen, J.T.De Silva, D.A.Chang, H.M.Fabiaña, N.Marti, J.Delgado, R.Martínez, A.Prats, L.Camps, P.Liou, C.W.Tan, T.Y.Liu, C.F.Cheng, H.H.Po, H.L.Lin, Y.J.Chou, C.L.Lin, C.H.Yen, C.C.Chang, Y.T.Hsu, Y.T.Lee, J.D.Lee, M.Huang, Y.C.Wu, C.Y.Huang, Y.C.Suwanwela, N.C.Chutinet, A.Likitjaroen, Y.Roongpiboonsopit, D.Charnwut, S.Dyker, A.Hossain, M.Muddegowda, G.K.Sanyal, R.Roffe, C.Natarajan, I.Finney, K.Sztriha, L.Teo, J.Chan, F.K.Lim, J.Chitando, B.Clarke, B.Patel, B.Khan, U.Ghatala, R.Trippier, S.Kalra, L.Manawadu, D.Sikondari, N.Aeron-Thomas, J.Sunman, W.Wilkes, G.Richardson, C.Buch, A.Jackson, B.Halse, O.Mashate, S.Wilding, P.Nguyen, V.Qadiri, M.R.Rashed, K.Board, S.Buckley, C.Smith, C.James, M.Keenan, S.Bouring, A.England, T.Donnelly, R.Scott, J.Maddula, M.Beavan, J.Perry, R.Francia, N.Watchhurst, C.Banaras, A.Ashton, A.Mistri, A.Musarrat, K.Eveson, D.Kallingal, J.Perez, J.Harrison, L.Marsden, T.Furnace, J.Clarke, R.Reid, J.Warburton, E.Macleod, M.J.Mitchell, J.Day, D.Church, N.Amis, E.Price, C.Rodgers, H.Whiting, R.Hussain, M.Harvey, M.Brown, S.Foot, J.Tryambake, D.Broughton, D.Bergin, A.Annamalai, A.Dixon, L.Weir, N.Blank, C.Harkness, K.Ali, A.Richards, E.Stocks, K.Bruce, D.W.Wani, M.Anjum, T.Krishnan, M.Nguyen Huy, T.Le Tuan, A. TruongCam, L. Dam ThiKim, T. Ngo ThiNguyen, B. PhamDat, A. NguyenVan, C. NguyenDuy, T. MaiViet, P. DaoTien, D. NguyenVan, T. VoLe Kim, K.Ngoc, T. BuiLe Thanh, T. TranHoanh, S. NguyenPhuoc, S. PhamVan, T. TranThi, B. DoanThu, H. Nguyen ThiDuy, M. NguyenVan, D. Ngo
Source
The Lancet; March 2019, Vol. 393 Issue: 10174 p877-888, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the target systolic blood pressure for optimal outcome is uncertain. We assessed intensive blood pressure lowering compared with guideline-recommended blood pressure lowering in patients treated with alteplase for acute ischaemic stroke.