학술논문
Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study
Document Type
Article
Author
Verstovsek, Srdan; Gerds, Aaron T; Vannucchi, Alessandro M; Al-Ali, Haifa Kathrin; Lavie, David; Kuykendall, Andrew T; Grosicki, Sebastian; Iurlo, Alessandra; Goh, Yeow Tee; Lazaroiu, Mihaela C; Egyed, Miklos; Fox, Maria Laura; McLornan, Donal; Perkins, Andrew; Yoon, Sung-Soo; Gupta, Vikas; Kiladjian, Jean-Jacques; Granacher, Nikki; Lee, Sung-Eun; Ocroteala, Luminita; Passamonti, Francesco; Harrison, Claire N; Klencke, Barbara J; Ro, Sunhee; Donahue, Rafe; Kawashima, Jun; Mesa, Ruben; Abulafia, Adi Shacham; Al-Ali, Haifa Kathrin; Andreasson, Bjorn; Angona, Anna; Ayala, Rosa; Bang, Soo-Mee; Bank, Bruce; Barraco, Fiorenza; Beggiato, Eloise; Benghiat, Fleur Samantha; Bonifacio, MassimiliaNo; Bories, Claire; Borsaru, Gabriela; Brabrand, Mette; Braester, Andrei; Broliden, Andes; Buxhofer-Ausch, Veronika; Cambier, Nathalie; Caramella, Marianna; Carpentier, Benjamin; Cascavilla, Nicola; Castellano, Maria Giraldo; Chang, Hung; Chen, Chih-Cheng; Cheong, June-Won; Choi, Yunsuk; Choi, Philip; Corsetti, Maria Teresa; Cuadrado, Isabel Montero; Cunningham, Julia; Damaj, Gandhi Laurent; De Stefano, Valerio; Delage, Robert; Delgado, Regina Garcĺa; Diaz, Jose Miguel Torregrosa; Dombi, Péter; Dubruille, Viviane; Egyed, Miklós; El Fassi, Daniel; Elinder-Camburn, Anna; Elli, Elena Maria; Ellis, Martin; Fava, Carmen; Fazal, Salman; Fleischman, Angela; Foltz, Lynda; Fox, Laura; Gabrail, Nashat; Garcĺa-Gutiérrez, Jose Valentĺn; Gerds, Aaron; Girault, Stephane; Gisslinger, Heinz; Gluvacov, Alexandru; Goh, Yeow Tee; Göthert, Joachim; Granacher, Nikki; Grosicki, Sebastian; Gupta, Vikas; Hadjiev (Hadzhiev), Evgeni (Evgueniy); Hafraoui, Kaoutar; Hamed, Aryan; Harrison, Claire; Hasselbalch, Hans; Hauser, Hanns; Heaney, Mark; Hebart, Holger; Hernandez Rivas, Jesus Maria; Higuero Saavedra, Victor; Hillis, Christopher; Hou, Hsin-An; How, Jonathan; Huang, Daniel; Hus, Marek; Illés, Arpad; Isidori, Alessandro; Iurlo, Alessandra; Ivanov, Vadim; Johansson, Peter; Jung, Chul Won; Kiladjian, Jean-Jacques; Kirgner, Ilya; Koren-Michowitz, Maya; Koschmieder, Steffen; Kosztolanyi, Szabolcs Ors; Kreiniz, Natalia; Kuykendall, Andrew; Lambert, Jonathan; Laribi, Kamel; Lascaux, Axelle; Lavie, Noa; Lavie, David; Lazaroiu, Mihaela; Leahy, Michael; Lech-Maranda, Ewa; Lee, Sung-Eun; Lee, Won Sik; Legrand, Ollivier; Lemoli, Roberto; Liang, James; Lim, Sung-Nam; Loschi, Michael; Lucchesi, Alessandro; Macarie, Ioan; Marolleau, Jean-Pierre; Martelli, Maurizio; Mayer, Jiri; McCloskey, James; McDermott, Christopher; McLornan, Donal; McMahon, Brandon; Mehta, Priyanka; Mesa, Ruben; Mikala, Gábor; Milojkovic, Dragana; Mineur, Philippe; Mishchenko, Elena; Moon, Joon Ho; Nagy, Zsolt; Narayanan, Srinivasan; O'Connell, Casey; Ocroteala, Luminita; Oh, Stephen; Ojeda-Uribe, Mario; Ong, Kiat Hoe; Otegbeye, Folashade; Palmer, Jeanne; Pane, Fabrizio; Passamonti, Francesco; Patriarca, Andrea; Perkins, Andrew; Pietrantuono, Giuseppe; Plander, Mark; Platzbecker, Uwe; Prasad, Ritam; Prejzner, Witold; Rachow, Tobias; Radinoff, Atanas; Rejtő, László; Rinaldi, Ciro; Robak, Tadeusz; Rodriguez, Maria Angeles Fernandez; Ronson, Aaron; Ross, David; Sacha, Tomasz; Sadjadian, Parvis; Salar, Antonio; Santillana, Guillermo Sanz; Scheid, Christof; Schmidt, Aline; Severinsen, Marianne Tang; Stoeva, Vera; Szwedyk, Paweł; Tiribelli, Mario; Trautmann-Grill, Karolin; Trottier, Amy; Tzvetkov, Nikolay; van Droogenbroeck, Janusz; Vannucchi, Alessandro; Verstovsek, Srdan; Vianelli, Nicola; von Bubnoff, Nikolas; Wolf, Dominik; Woszczyk, Dariusz; Woźny, Tomasz; Wróbel, Tomasz; Xicoy, Blanca; Yeh, Su-Peng; Yoon, Sung-Soo
Source
The Lancet; January 2023, Vol. 401 Issue: 10373 p269-280, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Janus kinase (JAK) inhibitors approved for myelofibrosis provide spleen and symptom improvements but do not meaningfully improve anaemia. Momelotinib, a first-in-class inhibitor of activin A receptor type 1 as well as JAK1 and JAK2, has shown symptom, spleen, and anaemia benefits in myelofibrosis. We aimed to confirm the differentiated clinical benefits of momelotinib versus the active comparator danazol in JAK-inhibitor-exposed, symptomatic patients with anaemia and intermediate-risk or high-risk myelofibrosis.