학술논문
The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins
Document Type
Article
Author
Source
Molecular Biology of the Cell; January 2015, Vol. 26 Issue: 2 p185-194, 10p
Subject
Language
ISSN
10591524; 19394586
Abstract
A central ubiquitin ligase involved in endoplasmic reticulum (ER)–associated protein degradation is the HRD-ligase. The ER-luminal subunit Hrd3 cooperates with the cochaperone Scj1 in clearing misfolded proteins from the ER.