학술논문
Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion
Document Type
Article
Author
Source
Molecular Biology of the Cell; November 2020, Vol. 31 Issue: 23 p2557-2569, 13p
Subject
Language
ISSN
10591524; 19394586
Abstract
Apoptotic cell extrusion is predicted to accumulate local tissue stresses that represent a mechanical cost for the epithelium, but how such costs may be alleviated is poorly understood. Here we identify a Src family kinase-mechanosensitive early immediate response of neighbor cells that relieves mechanical stress and allows extrusion to occur.