부산대학교 도서관

Diverse etiology of neuropathic pain conditions demands new understanding of its pathogenesis and development of effective therapy. Treatment of induced neuropathic pain using aqueous Adansonia digitatabark extract has not been investigated. We probed the systemic administration effects of A. digitatabark extract on sciatic nerve ligated induced neuropathic pain. Treatments with extract caused increased pain threshold on hot plate, hot- and cold-immersion test. Notably, an apparent decreased in systemic prostaglandin E2occurred concurrently with strengthened oxidative defense system. By contrast, extract-hexamethonium, -propranolol, -atropine or -prazosin cotreatments in induced-neuropathic rats suggested no involvement of muscarinic, nicotinic, beta or alpha-1 receptors in the analgesic action of the extract. Though, a weaken oxidative defense system was observed based on oxidative markers measured. These results indicate the crude extract ability to induce pain relief in neuropathic pain and this coincides with degree of decreased PGE2and increased antioxidants as well as decreased lipid peroxidation product. This is the first report demonstrating the usefulness of aqueous A. digitatabark extract in the management of neuropathic pain, an action that involves alteration of PGE2and oxidative defense system.