학술논문
Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease
Document Type
Article
Author
Verfaillie, Sander C.J.; Pichet Binette, Alexa; Vachon-Presseau, Etienne; Tabrizi, Shirin; Savard, Mélissa; Bellec, Pierre; Ossenkoppele, Rik; Scheltens, Philip; van der Flier, Wiesje M.; Breitner, John C.S.; Villeneuve, Sylvia; Aisen, Paul; Anthal, Elena; Appleby, Melissa; Ayranci, Gülebru; Barkun, Alan; Beaudry, Thomas; Bellec, Pierre; Benbouhoud, Fatiha; Bohbot, Veronique; Brandt, Jason; Breitner, John; Carmo, Leopoldina; Carrier Charles, Edouard; Chakravarty, Mallar; Cheewakriengkrai, Laksanun; Collins, Louis; Courcot, Blandine; Couture, Doris; Craft, Suzanne; Cuello, Claudio; Dadar, Mahsa; Dansereau, Christian; DasSamir; Marina, Dauar-Tedeschi; Dea, Doris; Debacker, Clement; Desautels, Rene; Dubuc, Sylvie; Duclair, Guerda; Dufour, Marianne; Eisenberg, Mark; El-Khoury, Rana; Etienne, Pierre; Evans, Alan; Faubert, Anne-Marie; Ferdinand, Fabiola; Fonov, Vladimir; Fontaine, David; Frappier, Josée; Joanne, Frenette; Gagne, Guylaine; Gauthier, Serge; Gervais, Valérie; Giles, Renuka; Gonneaud, Julie; Gordon, Renee; Hoge, Rick; Hyman, Bradley; Ituria-Medina, Yasser; Jack, Clifford; Kat, Justin; Kazazian, Christina; Khachaturian, Zaven; Knopman, David; Kostopoulos, Penelope; Labonte, Anne; Lafaille-Magnan, Marie-Elyse; Lee, Tanya; Leoutsakos, Jeannie-Marie; Lepage, Claude; Leppert, Illana; Madjar, Cécile; Mahar, Laura; Maillet, David; Maltais, Jean-Robert; Mathieu, Axel; Mathotaarachchi, Sulantha; Maultaup, Gerhard; Mayrand, Ginette; Meyer, Pierre-François; Michaud, Diane; Miron, Justin; Montine, Thomas; Morris, John; Münter, Lisa-Marie; Nair, Vasavan; Near, Jamie; Newbold-Fox, Holly; Orban, Pierre; Page, Véronique; Pascoal, Tharick; Petkova, Mirela; Picard, Cynthia; Pichet Binette, Alexa; Pogossova, Galina; Poirier, Judes; Pruessner, Jens; Rajah, Natasha; Rioux, Pierre; Rosa-Neto, Pedro; Sager, Mark; Saint-Fort, Eunice Farah; Savard, Mélissa; Sperling, Reisa; Tabrizi, Shirin; Tam, Angela; Tardif, Christine; Tariot, Pierre; Teigner, Eduard; Theroux, Louise; Thomas, Ronald; Toussaint, Paule-Joanne; Tremblay-Mercier, Jennifer; Tuwaig, Miranda; Vallee, Isabelle; Venugopalan, Vinod; Verfaillie, Sander; Villeneuve, Sylvia; Vogel, Jacob; Wan, Karen; Wang, Seqian; Yu, Elsa
Source
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; May 2018, Vol. 3 Issue: 5 p463-472, 10p
Subject
Language
ISSN
24519022
Abstract
Both subjective cognitive decline (SCD) and a family history of Alzheimer’s disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD.