학술논문
Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial
Document Type
Article
Author
Collins, Michael G; Fahim, Magid A; Pascoe, Elaine M; Hawley, Carmel M; Johnson, David W; Varghese, Julie; Hickey, Laura E; Clayton, Philip A; Dansie, Kathryn B; McConnochie, Rachael C; Vergara, Liza A; Kiriwandeniya, Charani; Reidlinger, Donna; Mount, Peter F; Weinberg, Laurence; McArthur, Colin J; Coates, P Toby; Endre, Zoltan H; Goodman, David; Howard, Kirsten; Howell, Martin; Jamboti, Jagadish S; Kanellis, John; Laurence, Jerome M; Lim, Wai H; McTaggart, Steven J; O'Connell, Philip J; Pilmore, Helen L; Wong, Germaine; Chadban, Steven J; Chadban, Steven J; Ying, Tracey; Gracey, David; Aouad, Leyla; Wyburn, Kate; Habijanec, Beatriz; Yeo, Hee-eun (Ellen); Lin, Lin; Rosales, Brenda; Hudaly, Julia; Rodrigues, Vera; Wong, Germaine; O'Connell, Philip; Murie, Penelope; Endre, Zoltan; Gray, Zuzana; Spicer, Rebecca; Durkan, Anne; Fahim, Magid A; Jegatheesan, Dev; Leary, Diana; Guo, Yujing (Sarah); Coburn, Amanda; Irvine, Rachael; McTaggart, Steven; Crawford, Aimee; Coates, P Toby; Hockley, Bronwyn; Fischer, Karen; Weinberg, Laurence; Mount, Peter; Baulch, Sarah; Claxton, Gayle; Harris, Saskia; Sidiropoulos, Sofia; Veenendal, Marieke; Kanellis, John; Barbis, Rita; Goodman, David; Anjalee, Anjalee; Le Page, Amelia; Jamboti, Jagadish; Chiam, Anna; Warger, Anne; Lim, Wai H; Collins, Michael; Pilmore, Helen; Dittmer, Ian; Manley, Paul; Ahmed, Jafar; McConnochie, Rachael; Newby, Lynette; Chen, Yan; Simmonds, Catherine; Irvine, John; Usher, Jenny; Clark, Carolyn; Beckett, Claire
Source
The Lancet; 20230101, Issue: Preprints
Subject
Language
ISSN
01406736; 1474547X
Abstract
Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a transplant to maintain intravascular volume and optimise graft function. Saline (0·9% sodium chloride) is widely used but might increase the risk of DGF due to its high chloride content. We aimed to test our hypothesis that using a balanced low-chloride crystalloid solution (Plasma-Lyte 148) instead of saline would reduce the incidence of DGF.