학술논문
Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study.
Document Type
Academic Journal
Author
Silverberg JI; Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.; Barbarot S; Department of Dermatology, Centre Hospitalier Universitaire de Nantes, 1 Place Alexis Ricordeau, 44000 Nantes, France.; Gadkari A; Health Economics and Outcomes Research, Regeneron, Tarrytown, NY, USA.; Simpson EL; Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.; Weidinger S; Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Mina-Osorio P; Medical Affairs, Regeneron, Tarrytown, NY, USA.; Rossi AB; Medical Affairs, Sanofi Genzyme, Cambridge, MA, USA.; Brignoli L; Kantar - Health Division, Paris, France.; Saba G; Kantar - Health Division, Paris, France.; Guillemin I; Health Economics and Value Assessment, Sanofi, Chilly-Mazarin, France.; Fenton MC; Real World Evidence, Sanofi Genzyme, Cambridge, MA, USA.; Auziere S; Kantar - Health Division, Paris, France.; Eckert L; Real World Evidence, Sanofi Genzyme, Cambridge, MA, USA. Electronic address: Laurent.Eckert@sanofi.com.
Source
Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Little is known on the current global prevalence of atopic dermatitis (AD) in the pediatric population.
Objective: To estimate the real-world global prevalence of AD in the pediatric population and by disease severity.
Methods: This international, cross-sectional, web-based survey of children and adolescents (6 months to <18 years old) was conducted in the following 18 countries: North America (Canada, United States), Latin America (Argentina, Brazil, Columbia, Mexico), Europe (France, Germany, Italy, Spain, United Kingdom), Middle East and Eurasia (Israel, Saudi Arabia, Turkey, United Arab Emirates, Russia), and East Asia (Japan, Taiwan). Prevalence was determined using the following 2 definitions: (1) diagnosed as having AD according to the International Study of Asthma and Allergies in Childhood (ISAAC) criteria and self- or parent-report of ever being told by a physician that they or their child child had AD (eczema); and (2) reported AD based on the ISAAC criteria only. Severity was assessed using the Patient Global Assessment (PtGA) and Patient-Oriented Eczema Measure (POEM).
Results: Among 65,661 responders, the 12-month diagnosed AD prevalence (ISAAC plus self-reported diagnosis) ranged from 2.7% to 20.1% across countries; reported AD (ISAAC only) was 13.5% to 41.9%. Severe AD evaluated with both PtGA and POEM was generally less than 15%; more subjects rated AD as mild on PtGA than suggested by POEM. No trends in prevalence were observed based on age or sex; prevalence was generally lower in rural residential settings than urban or suburban.
Conclusion: This global survey in 18 countries revealed that AD affects a substantial proportion of the pediatric population. Although prevalence and severity varied across age groups and countries, less than 15% had severe AD.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Objective: To estimate the real-world global prevalence of AD in the pediatric population and by disease severity.
Methods: This international, cross-sectional, web-based survey of children and adolescents (6 months to <18 years old) was conducted in the following 18 countries: North America (Canada, United States), Latin America (Argentina, Brazil, Columbia, Mexico), Europe (France, Germany, Italy, Spain, United Kingdom), Middle East and Eurasia (Israel, Saudi Arabia, Turkey, United Arab Emirates, Russia), and East Asia (Japan, Taiwan). Prevalence was determined using the following 2 definitions: (1) diagnosed as having AD according to the International Study of Asthma and Allergies in Childhood (ISAAC) criteria and self- or parent-report of ever being told by a physician that they or their child child had AD (eczema); and (2) reported AD based on the ISAAC criteria only. Severity was assessed using the Patient Global Assessment (PtGA) and Patient-Oriented Eczema Measure (POEM).
Results: Among 65,661 responders, the 12-month diagnosed AD prevalence (ISAAC plus self-reported diagnosis) ranged from 2.7% to 20.1% across countries; reported AD (ISAAC only) was 13.5% to 41.9%. Severe AD evaluated with both PtGA and POEM was generally less than 15%; more subjects rated AD as mild on PtGA than suggested by POEM. No trends in prevalence were observed based on age or sex; prevalence was generally lower in rural residential settings than urban or suburban.
Conclusion: This global survey in 18 countries revealed that AD affects a substantial proportion of the pediatric population. Although prevalence and severity varied across age groups and countries, less than 15% had severe AD.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)